February 02, 2021
Chang agreed with Goodman that the findings will shift
Chang, who was not involved in the research, said most doctors usually discuss
such risks with patients, based on suggestions of an elevated risk of heart
disease and stroke seen in smaller studies of people who have received hormone
therapy for other reasons.4 times higher compared to female controls, crate mold Manufacturers but women are less
likely to have a heart attack in that age group anyway..â€"I don’t think this
would dissuade anyone†from transitioning because the process is so important to
those who feel they need it, Dr. A higher risk may not have been seen in
transgender males because they receive their testosterone as an injection or a
patch, she speculated. Alice Chang, an assistant professor in the division of
endocrinology, metabolism, diabetes and nutrition at the Mayo Clinic in
Rochester, Minnesota, told Reuters Health by phone.When it came to the risk for
developing a stroke caused by a blood clot, the odds for transgender women were
9. The records of 48,686 men and 48,775 women who had not undergone gender
confirming treatment, all matched for race, ethnicity and year of birth, were
used for comparison. The risk seems to come from hormone therapy. We’re just
saying there are some questions that need to be answered to guide the
therapy.Taking hormone therapy as a transgender woman did not increase the odds
of a heart attack compared to non-transgender men in the control group.9 times
higher compared to men in the control group and 4.
But in the key subset that
had begun estrogen therapy, the odds of developing a potentially-dangerous clot
were 5.Clot rates were twice as high for all transgender women.1 times greater
after two years compared with non-transgender males. "Our hope is people will
understand we’re not trying to scare anybody. Risks comes with benefits, and
benefits come with risks. Until now, the data on whether gender confirming
medical therapy treatment poses cardiovascular risks has been sparse. "This is
the first large study that says we need to be aware of this (cardiovascular
risk) and a lot of unanswered questions about duration, type and dosing of
therapy have to be answered,†she said. It took about two years for the risks to
become clear, and they increased over time."These risks need to be weighed
against the important benefits of treatment,†he said. "There were so few events
because the patients tended to be young,†said Goodman.The study did not look at
specific formulations, combinations or doses of the hormones used in gender
confirming therapy, so it remains possible that some regimens pose a lower risk
than others and that’s where future research should focus, senior author Michael
Goodman, a professor of epidemiology at the Rollins School of Public Health at
Emory University in Atlanta, told Reuters Health in a telephone interview.The
Goodman study used the cases of 2,842 transgender women and 2,118 transgender
men.
Chang agreed with Goodman that the findings will shift the focus on the
safest way to give hormone treatments.The risk of a dangerous type of blood
clot, called a venous thromboembolism, nearly doubles for people transitioning
from male to female compared to both non-transgender men and women, researchers
reported in Annals of Internal Medicine. They were treated in California and
Georgia in the Kaiser Permanente health system. Among transgender women who had
started the therapy, the clot risk was five-fold higher after two years of
follow-up compared to non-transgender men and three times higher compared to
non-transgender women.1 times higher than for women in the control group, based
on a follow-up period of more than six years. It takes a thoughtful healthcare
provider and a well-educated patient to make an informed decision. They
typically had been followed for about four years and only about 23 percent had
undergone gender confirmation surgery. For transgender men, the researchers
could not confirm any health risks because number of incidents was too small.And
although women have lower rates of heart disease than men, the odds of stroke
and heart attack for transgender women remain the same as they would be if they
had not transitioned.Hormones given to people to align their sex with their
gender pose a significant risk of serious blood clots and stroke among
transgender women, one of the largest studies of transgender patients has
concluded. The risk was 2
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